Neonates and prematures are among the most transfused categories of patients . Adverse reactions due to transfusions, such as transfusion-transmitted infections, can affect the rest of their lives . In this systematic review, we revised the literature concerning transfusion-transmitted infection in neonates . We reported case-reports and case-series previously published and we integrated these data with our experience at local neonatal intensive care unit . Moreover, we illustrated strategies for mitigating transfusion-transmitted infections, including donor selection and testing, pathogen inactivation technologies and combined approaches, as for Cytomegalovirus infection, integrating leukoreduction and identification of seronegative donors.