Background: To identify factors predicting severe coronavirus disease 2019 (COVID-19) in adolescent and adult patients with laboratory-positive (quantitative reverse-transcription polymerase chain reaction) infection .
Method: A retrospective cohort study took place, and data from 740 subjects, from all 32 states of Mexico, were analyzed . The association between the studied factors and severe (dyspnea requiring hospital admission) COVID-19 was evaluated through risk ratios (RRs) and 95% confidence intervals (CIs).
Results: Severe illness was documented in 28% of participants . In multiple analysis, male gender (RR = 1.13 , 95% CI 1.06–1.20), advanced age ([ reference : 15–29 years old] 30–44, RR = 1.02 , 95% CI 0.94–1.11; 45–59, RR = 1.26 , 95% CI 1.15–1.38; 60 years or older, RR = 1.44 , 95% CI 1.29–1.60), chronic kidney disease (RR = 1.31 , 95% CI 1.04–1.64) and thoracic pain (RR = 1.16 , 95% CI 1.10–1.24) were associated with an increased risk of severe disease .
Conclusions: To the best of our knowledge, this is the first study evaluating predictors of COVID-19 severity in a large subset of the Latin-American population . Male gender and kidney illness were independently associated with the risk of severe COVID-19 . These results may be useful for health care protocols for the early detection and management of patients that may benefit from opportune and specialized supportive medical treatment.