Purpose To describe the clinical experience with the delivery of intravitreal injection therapy to patients with various indications at a tertiary university hospital during the COVID-19 lockdown in Jordan . Methods This is a retrospective observational study of patients who received intravitreal injections between April 12th and May 9th , 2020, a period during the national COVID-19 lockdown (March 16th to June 6th , 2020). Special medical and logistic arrangements, priority and visual risk assessment and strict infection control precautions were implemented . Demographics, diagnosis, intravitreal injection history, medical history, ophthalmic examinations and optical coherence tomography data were collected and analyzed . Results Intravitreal injections were successfully administered to 132 patients with diabetic retinopathy, age-related macular degeneration and retinal vein occlusion. All logistic and transmission control measures were followed by the medical staff and patients with no incidents . No new exposures or COVID-19 positive cases were traced to our location or time of therapy . No complications related to the injections were recorded . The mean period of delay due to the lockdown from the original scheduled appointment was six weeks . Mean visual acuity significantly decreased from 20/55 before the lockdown to 20/70 after the lockdown, and mean central macular thickness significantly increased from 329 to 370 μ . Conclusion The administration of intravitreal injection therapy during the COVID-19 lockdown under special safety precautions was feasible and successful . Resumption of the essential therapies and medical services during periods of pandemic restrictions while adhering to strict transmission control measures is encouraged.