Takotsubo syndrome (TTS), also called broken heart syndrome, is an acute and transient cardiac wall motion abnormality of the left ventricle . The patient prototype is a post-menopausal woman with myocardial infarction-like symptoms (angina pectoris, breathlessness, palpitations, etc .) who has experienced sudden emotional or physical stress . Although prognosis is generally considered relatively benign, both complications and recurrence rates are not insignificant . Pathophysiological mechanisms underlying TTS are not entirely understood, but the sympathetic system over-activity has a leading role . Moreover, since emotional stress frequently triggers TTS and since precedent diagnosis of psychiatric disorders sometimes coexists, the psychological response to stress could be another potential therapeutic target . Indeed, this article aims to explore the association between underlying depression and anxiety disorders and TTS, as well as to find ideal therapeutic options useful to treat and prevent TTS . Thus in our review, we considered case reports, case-control studies, and review articles from PubMed . Papers dealing with Takotsubo syndrome and anxiety disorder or depression were selected . We included papers published since 2010 and whose abstract was in English . We concluded that anxiety disorders, but not depression, are associated with a higher occurrence of TTS . There is a link between anxiety, TTS, and inflammation leading to increased sympathetic activity . Nevertheless, patients with pre-admission psychiatric disorders have a higher risk of recurrent TTS . Importantly, the use of selective serotonin reuptake inhibitors (SSRIs) could be a potential therapeutic aid in preventing TTS's recurrence in selected patients.