COVID-19 is a new disease leading to respiratory complications in adults . Children appear to have more modest symptoms than adults . Varicella is often described as a benign disease in the pediatric population . However, patients with varicella and COVID-19 co-infection can develop a more serious respiratory infection . We report the case of an infant who had a co-infection with both viruses that led to pleuropneumonia . The main question in the present case concerns the link between COVID-19 and varicella infection, and the possible modulation in immune response due to the two virus infections.