Opioid-free perioperative approaches hold promise to reduce opioid use after surgery and their associated side effects . Here, we report the perioperative analgesic plan of a patient who requested opioid-free care for an open partial hepatectomy . Opioid-free anesthesia care for abdominal surgery is usually dependent on epidural analgesia . However, as in this case, placing an epidural is not always an option due to contraindications such as infection, coagulopathy, or patient refusal . Our multimodal management plan provided an alternative opioid-free, epidural-free perioperative strategy that may prove useful for other patients undergoing similar surgeries.