Evaluation of a novel microsampling device for its use in clinical sample collection and biomarker analysis . Matching samples were collected from 16 healthy donors (ten females, six males; age 42 ± 20) via K2EDTA touch activated phlebotomy (TAP) device and phlebotomy . The protein profile differences between sampling groups was evaluated using aptamer-based proteomic assay SomaScan and selected ELISA . Somascan signal concordance between phlebotomy- and TAP-generated samples was studied and comparability of protein abundances between these blood sample collection methods was demonstrated . Statistically significant correlation in selected ELISA assays also confirmed the TAP device applicability to the quantitative analysis of protein biomarkers in clinical trials.
MeSH: Adult, Biomarkers, blood, Blood Proteins, analysis, Clinical Trials as Topic, Coronavirus Infections, blood, Enzyme-Linked Immunosorbent Assay, Female, Hemolysis, Humans, Male, Middle Aged, Pandemics, Phlebotomy, instrumentation, Pneumonia, Viral, blood, Proteomics, instrumentation, Young Adult