The world healthcare community continues to heroically rise to the challenge of the COVID-19 pandemic, from the frontline care givers to informatics professionals . Within the world of COVID-19, Clinical Informatics ’ response can be compared to Marvel™ X-Men, where evolution normally taking place over long years took place in a few short weeks . Major forward leaps in data use, utilizing big data for research because traditional studies that take years were not options, predictive analytic functionality retooled to help predict COVID-19, deployment of testing and medication research trials at a super-sonic pace, design and launch of new telehealth care models, and exponential growth in Information Technology (IT) infrastructure were driven by the need to develop a 'new normal' for safe and effective care for all patients . This article explores many of the rapid evolution improvements driven by the COVID-19 response . The environment of loosened regulations, support of collaborative practice between health systems and their vendors, and a global pressure to come up with solutions created the right primordial ooze for innovation to evolve at astonishing rates . From keeping up with the daily changes in regulations to the day by day support for an exhausted bedside clinician, Informaticists are key contributors to a successful strategy to address the pandemic . The articles also outlines several of the challenges Informatics has been able to help with and how technology is being leveraged to help respond.