Ivermectin (IVM) is a robust antiparasitic drug with an excellent tolerance and safety profile . Historically it has been the drug of choice for onchocerciasis and lymphatic filariasis global elimination programs . IVM is an oral insecticide and is a standard treatment against intestinal helminths and ectoparasites . The current humanitarian crisis in Venezuela is a regional public health threat that requires immediate action . The public health system in Venezuela has crumbled because of a 70% shortage of medicines in public hospitals, low vaccination campaigns, and the mass exodus of medical personnel . Herein we discuss the repurposing of IVM to attenuate the burden imposed by the most prevalent neglected tropical diseases (NTDs) in Venezuela, including soil-transmitted helminths, ectoparasites and, possibly, vector-borne diseases, such as malaria . In addition, novel experimental evidence has shown that IVM is active and efficacious in vitro against Chagas disease, Leishmaniases, arboviruses, and SARS-CoV-2 . In crisis-hit Venezuela, all these infectious diseases are public health emergencies that have long been ignored and require immediate attention . The versatility of IVM could serve as a powerful tool to tackle the multiple overlapping endemic and emergent diseases that currently affect Venezuela . The repurposing of this multipurpose drug would be a timely therapeutic approach to help mitigate the tremendous burden of NTDs nationwide.