Coronavirus disease 2019 (COVID-19) is an important and urgent threat to global health . Inflammation factors are important for COVID-19 mortality, and we aim to explore whether the baseline levels of procalcitonin (PCT), C-reaction protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) are associated with an increased risk of mortality in patients with COVID-19 . A retrospective study was conducted and a total of 76 patients with confirmed COVID-19 were included between January 17 , 2020 to March 2 , 2020, of these cases , 17 patients were dead . After adjusting covariates, PCT (≥ 0.10 ng/mL) and CRP (≥ 52.14 mg/L) exhibited independent increasing risks of mortality were used hazard ratio (HR) of 52.68 (95% confidence interval [CI]: 1.77-1571.66) and 5.47 (95% CI : 1.04-28.72), respectively . However, NRL (≥ 3.59) was not found to be an independent risk factor for death in our study . Furthermore, the elevated PCT levels were still associated with increasing risk of mortality in the old age group (age ≥ 60 y), and in the critically severe and severe patients after adjustment for complications . Thu Baseline levels of PCT and CRP have been addressed as independent predictors of mortality in patients with COVID-19.