BACKGROUND: Human papillomavirus (HPV) is the most prevalent sexually transmitted infection (STI) worldwide . Immunocompetent hosts have intact defense mechanisms to prevent HPV infection, but immunocompromised patients are at higher risks of complications including HPV related cancers . Most of these cancers originate from high-risk HPV strains in sexually active patients . CASE: Here we present a case of an immunocompromised adolescent who developed cervical cancer despite no prior sexually activity and only ever having low-risk type HPV on biopsy .
CONCLUSIONS: To our knowledge, this is the first case report of a cervical cancer arising from a low-risk HPV strain in an immunocompromised non-sexually active adolescent. This case highlights the importance of preventative and screening mechanisms in immunocompromised populations as they are at a higher probability of HPV related complications, even in absence of traditional risk factors.