Malignant gliomas are central nervous system tumors and remain among the most treatment-resistant cancers . Exome sequencing has revealed significant heterogeneity and important insights into the molecular pathogenesis of gliomas . Mutations in chromatin modifiers-proteins that shape the epigenomic landscape through remodeling and regulation of post-translational modifications on chromatin-are very frequent and often define specific glioma subtypes . This suggests that epigenomic reprogramming may be a fundamental driver of glioma . Here, we describe the key chromatin regulatory pathways disrupted in gliomas, delineating their physiological function and our current understanding of how their dysregulation may contribute to gliomagenesis.