BACKGROUND AND OBJECTIVES: Past history of stroke has been associated with an increased risk of a new ischemic stroke . Several studies have indicated increased prevalence of strokes among coronavirus patients . However, the role of past history of stroke in COVID19 patients is still unclear . The purpose of this systematic review is to evaluate and summarize the level of evidence on past history of stroke in COVID19 patients .
METHODS: A systematic review was performed according to the PRISMA guidelines was performed in PubMed, Embase, EBSCO Host, Scopus, Science Direct, Medline, and LILACS . Eligibility criteria: We evaluated studies including patients with diagnosis of COVID 19 and a past history of stroke . Risk of bias: was evaluated with the Newcastle- Ottawa Scale (NOS) and experimental studies were evaluated using the ROBINS-I scale .
RESULTS: Seven articles out of the total 213 articles were evaluated and included, involving 3244 patients with SARS VOC 2 Disease (COVID19) of which 198 had a history of cerebrovascular disease . Meta-analysis of the data was performed, observing an increase in mortality in patients with a history of cerebrovascular disease compared to those with different comorbidities or those without underlying pathology (OR 2.78 95% CI [1.42-5.46] pâ¯=â¯0.007; I2â¯=â¯49 %) showing adequate heterogeneity . The presence of publication bias was evaluated using the Egger test in a funnel plot, showing adequate . Asymmetry, indicating that there is no publication bias; however, due to the low number of included studies, we could not rule out or confirm the presence of bias .
CONCLUSIONS: The history of cerebrovascular disease was associated with a 2.78-fold increased risk of mortality compared to patients with other comorbidities or without underlying pathologies.