This study examined 100 widely viewed YouTube videos on COVID-19 vaccination . Information such as length, format, upload source, content, and cumulative views was coded . As of April 6 , 2020, the videos were viewed> 33 million times . Almost 75% were uploaded by news sources (garnering> 20 million views). While only 16% were uploaded by consumers, these videos garnered over 25% of cumulative views (n = 8,581,186 views). The majority of videos mentioned the vaccine manufacturing process (61.0 %) and 45.0% speculated on the amount of time needed to have a vaccine ready for use, which most often was thought to be 1-2 years . Even once the biological and technical aspects of vaccine development and manufacturing are accomplished, the benefits conferred on population health will also depend on public willingness to be vaccinated . Ongoing tracking of YouTube is needed to identify what is communicated about vaccines for COVID-19 . To the extent that public health officials learn how to create videos about the safety and effectiveness of a COVID-19 vaccine, which attract viewers, this could help increase awareness and interest about vaccination and help individuals make an informed decision about vaccine uptake.