The rapidly increased number of patients with COVID-19 resulted in the shortage of hospital beds . An outpatient follow-up plan was developed for COVID-19 patients with stable clinical condition and no concomitant diseases. The records of COVID-19 first admission clinic were retrospectively reviewed to identify the COVID-19 patients who were followed on home isolation as outpatients between March 17 , 2020 and April 18 , 2020 in Ankara, Turkey . Demographic and clinical characteristics of the patients, compliance with isolation rules, re-admission rates, and outcomes were investigated . A total of 41 patients with COVID-19 were followed on home isolation without hospitalization . The median age of the patients was 36 years . Twenty-four (58.5 %) of 41 patients were female . Twenty-nine (70.7 %) patients were healthcare workers . The most common symptoms at admission were cough, myalgia/arthralgia, and loss of smell and/or taste . Fourteen (34.1 %) patients were asymptomatic on the first admission . Anti-viral treatment was given to 27 (65.8 %) of 41 patients . Four of 41 patients were readmitted to the outpatient clinic and hospitalized . Three patients had worsening respiratory symptoms and pneumonia was detected in CT scans . One patient was hospitalized because of disseminated herpes zoster infection . Two patients who jeopardized the isolation rules were isolated and monitored at another hospital by provincial health directorate teams . If adequate conditions are provided, follow-up on home isolation seems to be a feasible method in carefully selected patients . However, these patients should be monitored closely by an experienced team during the isolation period.