Neurological sicknesses are serious, multifactorial, debilitating disorders that may cause neurodegeneration . Neuroprotection is the protection of the structure and capacity of neurons from affronts emerging from cell injuries instigated by an assortment of specialists or neurodegenerative diseases . Various neurodegenerative diseases, including Alzheimer's, Parkinson's, and epilepsy, afflict many people worldwide, with increasing age representing the leading risk factor . Crocin is a natural carotenoid compound which was found to have therapeutic potentials in the management of the neurological disease . In this review, we focused on the restorative capabilities of Crocin as a neuroprotective agent . The general neuroprotective impact and the various conceivable basic components identified with Crocin have been examined . In light of the substantial proof indicating the neuro-pharmacological viability of Crocin to different exploratory standards, it is concluded that Crocin exerts direct antioxidant, antiapoptotic and anti-inflammatory activities by multiple signaling pathways . Besides, Crocin was found to elevate dopamine level in the brain during the experimental model of Parkinson's disease . Thus, this compound has been demonstrated to be a promising option for the treatment of neurodegenerative diseases, with few adverse effects . It ought to be further considered as a potential contender for neuro-therapeutics, concentrating on the mechanistic and clinical evidence for its effects.