To cope with Covid-19 and limits its spread among residents, retirement homes have prohibited physical contact between residents and families and friend and, in some cases, even between residents or between residents and caregivers . We investigated the effects of measures against Covid-19 on the mental health of participants with Alzheimer's disease (AD) who live in retirement homes in France . We instructed on-site caregivers to assess depression and anxiety in participants with mild AD who live in retirement homes . Fifty-eight participants consented to participate in the study . The participants rated their depression and anxiety during and before the Covid-19 crisis . Participants reported higher depression (p = .005) and anxiety (p = .004) during than before the Covid-19 crisis . These increases can be attributed to the isolation of the residents and/or to the drastic changes in their daily life and care they receive . While, in their effort to prevent infections, retirement homes are forced to physically separate residents from the outside world and to drastically reduce residents' activities, these decisions are likely to come at a cost to residents with AD and their mental health.