Although the COVID-19 pandemic shows no signs of abating, public health strategies have transitioned from containment to harm reduction . In light of this paradigm shift, it is critical that individuals take steps to prevent the spread of SARS-CoV-2, the virus that causes COVID-19 . In the United States, the CDC recommends that individuals wear face coverings in public places, such as grocery stores . As lockdowns are being phased out around the world, authorities are requiring the use of such masks in public places while maintaining social distance . Individuals (including healthcare professionals outside of their clinical settings) and manufacturers are following the CDC ’ s recommendation . But, many currently available masks are not form-fitting, are not customizable, and are uncomfortable with even short-term use, thereby undercutting their effectiveness . Moreover, because cotton absorbs and retains the moisture found in an exhaled breath masks made of cotton have the potential to increase the wearer ’ s risk of infection . Thus, as we shift to harm reduction and social distancing measures relax, it is imperative that these shortcomings in fabric masks are addressed and that is the motivation for this research . The overall objective of the research is to design, develop, and test a fabric mask that is effective while being comfortable during continuous use over long periods of time . As the first step in the design process, we reviewed the modes of transmission of SARS-CoV-2 virus . We analyzed a medical mask and a fabric mask in the market and identified their shortcomings . We carried out an in-depth analysis of user needs and developed the performance requirements of the proposed mask . We defined the architecture of the mask comprising the following principal components: Barrier, Form-Fitting, Positioning, and Fastening . We tested and evaluated candidate materials for the components and developed the design specifications and construction details for the mask . We produced the mask and carried out subjective testing on a user in a typical workplace setting; we demonstrated that the mask was form-fitting, customizable, washable, and could be worn continuously and routinely over extended periods of time by individuals and therefore could serve as an effective means to reduce the harm from SARS-CoV-2.