OBJECTIVE: To discuss the effects of Lianhua Qingwen granules plus arbidol on treatment of mild corona virus disease-19 (COVID-19).
METHODS: A total of 295 COVID-19 patients (2020.2.17-2020.3.6) in Wuhan Third Hospital were chosen and randomly assigned to control group (n=148) and observation group (n=147). The control group orally took arbidol and the observation group took Lianhua Qingwen granules and arbidol . TCM symptom scores, white blood count (WBC), lymphocyte count (LYM), C-reactive protein (CRP), procalcitonin (PCT) and chest CT review conditions were compared .
RESULTS: Total effective rate in the observation group was significantly higher than control group (( 80.95% vs. 64.86 %); severe transfer rate in the observation group was lower than control group (14.29% vs. 23.65 %) (P＜0.05); after 7 d of treatment, TCM syndromes like fever, weakness, cough, throat dryness and sore and chest discomfort, CRP and PCT levels in the observation group were significantly lower than control group (P＜0.05); WBC and LYM levels in the observation group were significantly higher than control group (P＜0.05); based on CT review, effective cure rate in the observation group (69.39 %) and control group (62.84 %) was not significantly different (P＞0.05). Both of groups had no serious adverse reactions .
CONCLUSION: Lianhua Qingwen granules combined with arbidol can relieve the clinical symptoms, adjust the inflammatory factors, increase the curative effects and reduce the severe transfer rate.