We are facing an unprecedented time during the COVID-19 pandemic . Measures have been taken to reduce the spread of the virus, including school closures and widespread lockdowns . Physical isolation combined with economic instability, fear of infection, and uncertainty for the future has had a profound impact on global mental health . For adolescents, the effects of this stress may be heightened due to important developmental characteristics . Canadian adolescents (n = 1,054; M age= 16.68, SD = 0.78) completed online surveys and responded to questions on stress surrounding the COVID-19 crisis, feelings of loneliness and depression, as well as time spent with family, virtually with friends, doing schoolwork, using social media, and engaging in physical activity . Results showed that adolescents are very concerned about the COVID-19 crisis and are particularly worried about schooling and peer relationships . COVID-19 stress was related to more loneliness and more depression, especially for adolescents who spend more time on social media . Beyond COVID-19 stress, more time connecting to friends virtually during the pandemic was related to greater depression, but family time and schoolwork was related to less depression . For adolescents with depressive symptoms, it may be important to monitor the supportiveness of online relationships . Results show promising avenues to stave off loneliness, as time with family, time connecting to friends, as well as physical activity were related to lower loneliness, beyond COVID-19 stress . These results shed light on the implications of the COVID-19 pandemic for adolescents and document possible pathways to ameliorate negative effects.