Severe acute respiratory syndrome (SARS-CoV), Middle East respiratory syndrome (MERS) and SARS-CoV-2 are related to the coronaviridae family . The worldwide pandemic of the new coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan province of China, in December 2019, and spread rapidly throughout the world . More than 6 million cases and 370,000 deaths had been reported by 31 May 2020 in more than 200 countries . No data are available from any clinical trials supporting a proposed prophylactic therapy . More than 300 active clinical trials are currently underway . Many drugs have been studied against COVID-19, but there is no actual evidence from any randomized clinical trials with a potential therapy that can improve outcomes of a patient diagnosed with COVID-19 . In some cases, many of the investigated drugs cause side effects, e.g . chloroquine, ribavirin. Besides its beneficial effects such as reducing disease progression and decreasing symptom duration, chloroquine can cause cardiac side effects . Ribavirin, on the other hand, is recognized as a teratogen and considered unsafe in pregnancy . No special effective antiviral therapy against COVID-19 is currently available . Although the course of the disease is mild and moderate in the majority of the COVID-19 patients, more than 5% -7% of the patients' life being under severely susceptible threats requires more effective medicinal products, urgently.