Cruise ships transport a significant number of people in confined spaces over an extended period than other modes of transportation, thereby presenting a unique environment to elevate human-to-human transmitted infections . The overcrowded public rooms, congested accommodations, standard food sup-plies, and shared sanitary facilities encourage the transmission of infectious diseases by affected persons and through contaminated food, water and sur-faces . A novel coronavirus (COVID-19) originating from Wuhan, China in November 2019 spread globally . Unfortunately, Diamond Princess is the first cruise ship on board to have an outbreak of COVID-19 with 3711 passengers and crew members . It began from Yokohama on January 20 , 2020, and was supposed to return to Yokohama on February 3 2020 . An 80-year-old male passenger, who debarked in Hong Kong on January 25 2020, tested positive for COVID-19 on February 1 . Diamond Princess was immediately ordered to stay in the ocean and follow quarantine measures near Yokohama from February 3 onwards . Several other cruise ships such as the Grand Princess, MS Wester-dam, Zaandam, etc . had COVID-19 outbreaks onboard . The failure to isolate the crew at the very beginning of quarantine resulted in further transmission of the virus to the passengers and crew . In conclusion, the compact conditions in the cruise ships with high population density amplified the transmission of COVID-19, mainly driven by contact rate and mixing effects.