This contribution focusses on equity and COVID-19 by comparing the urban responses in four cities: Sydney, Milan, Seoul and London . Key features of urban life, such as connectivity and interaction, accelerate the spread of COVID-19 . We show some dimensions of urban health responses to minimise the spread of the 2019 novel coronavirus (SARS-CoV-2) in the population and how in this early phase cities have mainly implemented national policies . We look at sociospatial relations, including scale, and equity in cities and at the way the pandemic is reinforcing existing, and creating new, inequities . The proactive and empowered input from cities is critical as we simultaneously prepare for recovery and for subsequent waves of infection.