The global spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that causes COVID19 has become a source of grave medical and socioeconomic concern to the human society . Since its first appearance in the Wuhan region of China in December 2019, the most effective measures of managing the spread of SARS-CoV-2 infection have been social distancing and lockdown of human activity; the level of which has not been seen in our generations . An effective control of the viral infection and COVID-19 will ultimately depend on the development of either a vaccine or therapeutic agents . This article highlights the progresses made so far in these strategies by assessing key targets associated with the viral replication cycle . The key viral proteins and enzymes that could be targeted by new and repurposed drugs are discussed.