Since the beginning of the 21st century, several viral outbreaks have threatened humankind and posed a new challenge to the modern healthcare system . The recent outbreak in Wuhan (December 2019), China, represents a beta coronavirus classified as novel Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) which belongs to the Coronaviridae family . Novel SARS-CoV-2 represents a significant similarity with previous coronaviruses such as SARS-CoV in 2002, China and MERS-CoV in 2015, Middle East . However, preliminary research investigations have shown the novel SARS-CoV-2 evolved with several mutations and developed the capacity to cross the species, i.e., animal to human . The initial findings have shown that spike proteins are vital molecules target hACE2 receptor for its attachment and entry into cells . After successful entry virus primarily focuses on respiratory airway cell lines and triggers a massive immune response leading to mucus generation . In severe conditions, the virus is capable of forcing viral pneumonia leading to the collapse of the respiratory system, i.e., COVID19 . So far, there is a lack of immunity against the virus in humans . At the same in the absence of therapeutic interventions, many countries experienced high mortality, such as the United States, European countries, i.e., Italy, Spain, France, and the United Kingdom . The vaccine development is underway and experiencing challenges, as many reports demonstrated genetic variations in viral genome and proteins as well . The present study provides a complete comprehensive overview of the novel SARS-CoV-2 outbreak, human transmission, and global spread.