2019-nCoV has spread rapidly around the world, posing a major threat to global public health systems . This is the third time that a highly pathogenic coronavirus has emerged in the human population during the past 20 years . Researchers have conducted a number of studies since the coronavirus epidemic broke out, but there are no specific drugs or vaccines for coronavirus . Therefore, further systematic research on coronavirus is still needed . This review focused on the structure, life cycle and pathogenesis of coronavirus and summarized the current progress in detection approaches, treatment strategies and vaccines for COVID-19 with a view to provide references for further research.