Caucasian whortleberry (Vaccinium Arctostaphylos L.) is rich in anthocyanins, which possesses a wide range of biological and pharmaceutical activities . Electrochemical behavior of V. Arctostaphylos extract of dried fruit was performed by cyclic voltammetry and differential pulse voltammetry in aqueous solution . The results show that the level of delphinidin 3-O-glucoside (D3-OG) compound is higher than petunidin 3-O-glucoside (P3-OG) and malvidin 3-O-glucoside (M3-OG) level . This extract has a high solubility in water, and the potential-pH diagram indicates that the D3-OG capable oxidized to D3-OGOX with two electron/two proton process . D3-OG compound has a high antioxidant power because of the oxidation peak potential is low . Furthermore, total antioxidant capacity (1.475 C g-1) was determined by charges under of first oxidation peak . The antioxidant activity of three anthocyanins against Xanthine oxidase, Myeloperoxidase, NADPH oxidase, cytochrome P450 3A4 and 2B4 (ROS generation enzymes) has been performed through molecular docking studies . The results indicated that all the anthocyanins (D3-OG, P3-OG and M3-OG) bound exclusively to the binding site of ROS generation enzymes and have a remarkable role in suppressing the destructive effects of oxidative stress in the biological system of the human body . Also, D3-OG as a major anthocyanin of Vaccinium Arctostaphylos L. extract has an inhibition effect against the COVID-19 outbreak . Electrochemical approaches provided a simple, fast, low cost, green, and high sensitivity methods for investigation of electroactive compounds in plant extracts.