Diabetes is considered as one of the main comorbidities linked to the severity of respiratory syndrome coronavirus 2 . For people living with diabetes, even a minor illness can lead to dangerously high blood sugar levels . This may cause life-threatening complications, such as diabetic ketoacidosis or a hyperosmolar hyperglycaemic state . Literature has been found that 20–50% affected patients of COVID-19 pandemic are diabetic . Diabetic patients are highly affected due to increased viral entry into the cell, decrease immunity . Here are several hypotheses to explain the increased incidence and severity of COVID-19 infection in people with diabetes. Several cytokines are liberated in diabetics which can play a more deleterious role in Covid-19 infection . The severe acute respiratory syndrome (SARS) -CoV2, coronavirus pandemic highlights the importance of understanding shared disease pathophysiology, potentially informing therapeutic choices in individuals with Type 2 diabetes. Thus, knowledge about the potential mechanisms in between diabetes & the novel coronavirus is of utmost importance To managed diabetes, and individuals need to face challenges in the current trends in this pandemic crisis . For oral health professional, the management of diabetes should follow the protocol for the treatment of individuals with diabetes. This review illustrates the mechanisms by which diabetes modulates the host-viral interaction, hostimmune responses and guidelines to manage during an illness.