Acute and subacute stent thromboses are rare but life-threatening complications of primary coronary intervention and stenting . We present a case of a patient with COVID-19 infection who presented with pneumonia, acute respiratory failure, and non–ST elevation myocardial infarction . Reperfusion was achieved with coronary angioplasty and drug-eluting stent placement, and the patient was started on aspirin and clopidogrel. However , 72 hours later, the patient experienced an episode of subacute stent thrombosis . This raises concerns about a possible association between stent thrombosis and increased thrombogenicity and platelet aggregability triggered by COVID-19 infection.