As rates of novel coronavirus disease 2019 (COVID-19) continue rising in Africa, usage of infection prevention and control (IPC) strategies by healthcare workers (HCW) is critical . We highlight a Cochrane review of qualitative evidence that explored barriers and facilitators to HCW compliance with IPC recommendations for COVID-19 and other respiratory infectious diseases . The review found various individual-and organizational-level barriers and facilitators . The findings suggest that healthcare system constraints that make it difficult for healthcare workers to implement IPC guidelines require urgent prioritisation . This will help lay the foundation for addressing the more individual-level barriers potentially discouraging HCW from implementing IPC guidelines . We draw attention to pan-African initiatives for enhancing healthcare workers ’ capacity to undertake IPC measures at such a critical time.