The ongoing virus impact in the whole world is COVID19 infection has led to unprecedented crisis paving to outrage of the world citizens The highly contagious virus started its spread from the China during the month of late November 2019 and spread to all over the world The COVID-19 pandemic led catastrophe and earlier episodes of similar epidemic SARS outbreaks in China and Middle East interrogate the preparedness in handling such predicament The major symptomatic manifestations of patients are not so accurate and vary from one person to another and higher frequency of asymptomatic cases often misled diagnosis, unless the CT chest scan findings affirms the disease progress into fatal SARS Disambiguation over the other viral respiratory illnesses similar to COVID-19 needs to be meticulously handled by emphasize on simultaneous co-detection of multiple viral pathogens Henceforth, robust diagnostic tools are necessitated to substantiate suspected cases and to screen large population in less time This review would keenly focus on the challenging prime requisite for accurate laboratory testing of the infection and the potentials of various techniques in investigating the pandemic