To measure the occurrence of protective behaviors for COVID-19 and sociodemographic factors according to the occurrence of multimorbidity in the Brazilian population aged 50 or over was the objective of this study . We used data from telephone surveys among participants of ELSI-Brazil (Brazilian Longitudinal Study of Aging), conducted between May and June 2020 . The use of non-pharmacological prevention measures for COVID-19, reasons for leaving home according to the presence of multimorbidity and sociodemographic variables were evaluated . among 6,149 individuals . Multimorbidity was more frequent in females, married, aged 50-59 years and residents of the urban area . Most of the population left home between once and twice in the last week, increasing according to the number of morbidities (22.3% no morbidities and 38% with multimorbidity). Leaving home every day was less common among individuals with multimorbidity (10.3 %) and 9.3% left home in the last week to access health care . Hand hygiene (> 98 %) and always wearing a mask when leaving home (> 96 %) were almost universal habits . Greater adherence to social isolation was observed among women with multimorbidity when compared to men (PR = 1.49 , 95% CI : 1.23-1.79). This adherence increased proportionally with age and inversely with the level of education . The protective behavior in people with multimorbidity seems to be greater in relation to the others, although issues related to social isolation and health care deserve to be highlighted . These findings can be useful in customizing strategies for coping with the current pandemic.