Introduction: Obesity, diabetes, hypertension and age have been pointed at as factors that influence on the progression of COVID-19; however, evidence for other conditions is inconclusive .
Objective: To identify which clinical characteristics are related to COVID-19 severity and to determine whether age acts a modifier of the relationship between cardio-metabolic comorbidities (CMC) and COVID-19 progression .
Method: Data on & #8805; 20-year-old confirmed cases (n = 159,017) were analyzed . Hospitalization, development of pneumonia, intubation requirement, intensive care unit admission and death were the dependent variables in Poisson regression models estimation, whereas the interaction between age and different CMCs were the independent variables .
Results: Having CMCs, as well as other comorbidities, was directly related to COVID-19 progression, whereas chronic obstructive pulmonary disease was only related to an increase in the risk of dying . The risk for COVID-19 severity was lower as age was more advanced . Asthma and smoking were not risk factors for the progression of COVID-19 . Conclusion: In the Mexican population, the risk of COVID-19 progression associated with comorbidities was higher in young adults.