Performance characteristics of a rapid SARS-CoV-2 antigen detection assay at a public plaza testing site in San Francisco
Authors: Pilarowski Genay, Lebel Paul, Sunshine Sara, Liu Jamin, Crawford Emily, Marquez Carina, Rubio Luis, Chamie Gabriel, Martinez Jackie, Peng James, Black Douglas, Wu Wesley, Pak John, Laurie Matthew T, Jones Diane, Miller Steve, Jacobo Jon, Rojas Susana, Rojas Susy, Nakamura Robert, Tulier-Laiwa Valerie, Petersen Maya, Havlir Diane V, DeRisi Joseph Published on:
2021
Publication:
J. infect. dis DOI:-
We evaluated the performance of the Abbott BinaxNOW TM Covid-19 rapid antigen test (Binax-CoV2) to detect virus among persons, regardless of symptoms, at a public plaza site of ongoing community transmission. Titration with cultured SARS-CoV-2 yielded a human observable threshold between 1.6x10 4-4.3x10 4 viral RNA copies (cycle threshold (Ct) of 30.3-28.8). Among 878 subjects tested, 3% (26/878) were positive by RT-PCR, of which 15/26 had Ct<30, indicating high viral load. 40% (6/15) of Ct<30 were asymptomatic. Using this Ct<30 threshold for Binax-CoV2 evaluation, the sensitivity of Binax-CoV2 was 93.3% (14/15), 95% CI: 68.1-99.8%, and the specificity was 99.9% (855/856), 95% CI: 99.4-99.9%.
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Journal:
Journal Article
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WHO: 6wj756y6
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article_id: 564686
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