Shortages in N95 filtering facepiece respirators (FFRs) are significant as FFRs are essential for the protection of healthcare professionals and other high-risk groups against Coronavirus Disease of 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 . In response to these shortages during the ongoing COVID-19 pandemic, the Food and Drug Administration issued an Emergency Use Authorization (EUA) permitting FFR decontamination and reuse . However, although industrial decontamination services are available at some large institutions, FFR decontamination is not widely available . Effective FFR decontamination must 1) deactivate the virus; 2) preserve FFR integrity, specifically fit and filtering capability; and 3) be non-toxic and safe . Here we identify and compare at-home methods for heat-based FFR decontamination that meet these requirements, but utilize common household appliances . Our results identify viable protocols for simple and accessible FFR decontamination, while also highlighting methods that may jeopardize FFR integrity and should be avoided.