Purpose: To evaluate the visual acuity, quality of vision and patient reported outcomes for patients that were either bilaterally implanted with a trifocal intraocular lens (IOL) or an extended depth of focus (EDOF) IOL .

Design: Single site, prospective, non-interventional, masked, two-arm comparative study .

Methods: Subjects who had prior uncomplicated cataract surgery with bilateral implantation of one of the lenses above were evaluated . Subjects in each group were assessed during a single visit . The uncorrected and best distance-corrected binocular near (40 cm), intermediate (60 cm), and distance visual acuity (VA) were measured, along with a spectacle independence questionnaire, a quality of vision questionnaire and contrast sensitivity measured in both mesopic and photopic conditions .

Results: The study included 23 EDOF and 25 trifocal subjects . Binocular Uncorrected VAs were similar at distance and intermediate, but about 1.5 lines better at near with the trifocal (p <0.001). Binocular best corrected distance - VA was significantly better with the EDOF lens (0.5 lines, p <0.001), though the mean VA was better than 20/20 in both groups . Distance-corrected intermediate and near VA were significantly better with the trifocal IOL (1 line and 1.5 lines respectively, p <0.001). Significantly more trifocal subjects had 20/25 or better VA at all three test distances (64% vs 4%, p <0.001). Patient reported spectacle independence was significantly higher in the trifocal group, driven primarily by differences in near vision . Mesopic and photopic binocular contrast sensitivity, satisfaction and subjective quality of vision scores were similar between groups . Conclusion: The trifocal IOL provided significantly better near vision (1.5 lines) with slightly worse distance vision (0.5 lines), while providing similar contrast sensitivity and visual quality . It may be the preferred choice for patients desiring more spectacle independence.