Excessive inflammation and malnutrition are associated with coronavirus disease 2019 (COVID-19) severity and mortality . Combined biomarkers of malnutrition and inflammation, such as serum prealbumin, might be particularly attractive for early risk stratification . We conducted a systematic review and meta-analysis of studies reporting serum prealbumin in patients with COVID-19 . We searched PubMed, Web of Science and Scopus, between January and November 2020, for studies reporting data on serum prealbumin, COVID-19 severity, defined as severe illness, prolonged viral load, receiving mechanical ventilation or admitted to intensive care unit (ICU), and mortality . Nineteen studies in 4,616 COVID-19 patients were included in the meta-analysis . Pooled results showed that serum prealbumin concentrations were significantly lower in patients with severe disease and non-survivors (standard mean difference, SMD, -0.92 , 95% CI, -1.10 to -0.74, P <0.001). Extreme heterogeneity was observed (I 2 = 77.9% ; P <0.001). In sensitivity analysis, the effect size was not significantly affected when each study was in turn removed (range between -0.86 and -0.95). The Begg's (P = 0.06) and Egger's t -tests (P = 0.26) did not show publication bias . Pooled SMD values were significantly and negatively associated with age (t = -2.18, P = 0.045) and C-reactive protein (t = -3.85, P = 0.002). In our meta-analysis, lower serum prealbumin concentrations were significantly associated with COVID-19 severity and mortality . This combined marker of malnutrition and inflammation might assist with early risk stratification and management in this group.
Index: COVID-19, biomarker, disease severity, mortality, prealbumin