It ’ s since December 2019 that Corona virus disease (COVID-19) has emerged to be the global issue of concern . A “ pandemic ”; this is what WHO has declared about the COVID-19 outbreak on March 3rd , 2020 . Vitamin D and its deficiency have recently been claimed to be one of the potential factors affecting COVID-19 risks and outcomes . As Selberstein et al., has recently discussed the effect of vitamin D deficiency, and the role of vitamin D supplementation in COVID-19 patients , I ’ d believe that vitamin D binding protein (DBP) is maybe also involved . A closer look on DBP and its action on regulating the circulatory vitamin D levels, its polymorphisms and their impact on COVID-19 prevalence and mortality, will be briefly discussed.