The outbreak of the SARS-Cov-2 pandemic is triggering a global health emergency alert . Until vaccination becomes available, a bundle of effective preventive measures is desperately needed . Recent research is indicating the relevance of aerosols in the spread of SARS-CoV-2 . Thus, in this study commercially available antiseptic mouthwashes based on the actives chlorhexidine digluconate (CHX) and octenidine dihydrochloride (OCT) were investigated regarding their efficacy against SARS-CoV-2 using the European Standard 14476 . Based on the requirement of EN 14476 in which reduction of at least four decimal logarithms (log10) of viral titer is requested to state efficacy, the OCT-based formulation was found to be effective within a contact time of only 15 sec against SARS-CoV-2 . Based on this in vitro-data the OCT-mouthwash thus constitutes an interesting candidate for future clinical studies to prove its effectiveness in a potential prevention of SARS-CoV-2 transmission by aerosols.