Coronaviridae constantly infect human and animals causing respiratory, gastroenteric or systemic diseases . Over time, these viruses have shown a marked ability to mutate, jumping over the human-animal barrier, thus becoming from enzootic to zoonotic . In the last years, numerous therapeutic protocols have been developed, mainly for severe acute respiratory syndromes in humans . The aim of this review is to summarize drugs or other approaches used in coronavirus infections focusing on different roles of these molecules or bacterial products on viral adhesion and replication or in modulating the host's immune system . Within the “ One Health ” concept, the study of viral pathogenic role and possible therapeutic approaches in both humans and animals is essential to protect public health.