The severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019, COVID-19) pandemic has placed a tremendous burden on healthcare systems globally . Therapeutics for treatment of the virus are extremely inconsistent due to the lack of time evaluating drug efficacy in clinical trials . Currently, there is a deficiency of published literature that comprehensively discusses all therapeutics being considered for the treatment of COVID-19 . A review of the literature was performed for articles related to therapeutics and clinical trials in the context of the current COVID-19 pandemic . We used PubMed, Google Scholar, and Clinicaltrials.gov to search for articles relative to the topic of interest . We used the following keywords: “ COVID-19 ”, “ therapeutics ”, “ clinical trials ”, “ treatment ”, “ FDA ”, “ ICU ”, “ mortality ”, and “ management ” . In addition, searches through the references of retrieved articles was also performed . In this paper, we have elaborated on the therapeutic strategies that have been hypothesized or trialed to-date, the mechanism of action of each therapeutic, the clinical trials finished or in-process that support the use of each therapeutic, and the adverse effects associated with each therapeutic . Currently, there is no treatment that has been proven to provide significant benefit in reducing morbidity and mortality . There are many clinical trials for numerous different therapeutic agents currently underway . By looking back and measuring successful strategies from previous pandemics in addition to carrying out ongoing research, we provide ourselves with the greatest opportunity to find treatments that are beneficial.