Objectives: We sought to determine the estimated glomerular filtration rate (eGFR) among patients with COVID-19 and to examine its correlation with different demographic, clinical, and laboratory characteristics .
Methods: This study examined patients diagnosed with COVID-19 and enrolled at Al Kuwait Hospital, Dubai, UAE . eGFR was calculated using the Modification of Diet in Renal Disease equation , 186 × (SCr mg/dL) -1.154 × (age) -0203 × 0.742 [if female] × 1.212 [if black], and compared for 250 COVID-19 cases and 153 non-COVID-19 controls . Analysis were performed using univariate statistics .
Results: The overall mean age of the cohort was 47.2±14.0 years, and 54.6% (n = 220) were males . The results showed that 45.3% of COVID-19 patients had mild-severe renal impairment, as reflected in the eGFR . When compared to patients with normal eGFR, those with severe renal impairment were older (62.5 vs. 40.2 years; p <0.001), more likely to be male (100% vs. 71.1% ; p = 0.016), and have comorbidities (90.9% vs. 40.0% ; p <0.001) including diabetes mellitus (72.7% vs. 21.5% ; p <0.001) and hypertension (72.7% vs. 25.2% ; p = 0.003). They were also more likely to be associated with those that had severe (36.4% vs. 25.9% ; p <0.001) and critical (63.6% vs. 16.3% ; p <0.001) COVID-19 infection as well as intensive care unit admission (72.7% vs. 16.3% ; p <0.001). Correlational analysis showed a significant association between renal function indicators and different laboratory markers, including hematological indices and different liver enzymes .
Conclusions: This is the first study to examine the renal function among COVID-19 cases in the Middle East. Nearly half of COVID-19 patients had moderate to severe renal impairment . Diabetes mellitus and hypertension were the most common underlying comorbidities associated with moderate-severe renal function impairment among COVID-19 patients.