In less than 6 months, COVID-19 spread rapidly around the world and became a global health concern . Hypertension is the most common chronic disease in COVID-19 patients, but its impact on these patients has not been well described . In this retrospective study, 82 patients diagnosed with COVID-19 were enrolled, and epidemiological, demographic, clinical, laboratory, radiological and therapy-related data were analyzed and compared between COVID-19 patients with (29 cases) or without (53 cases) hypertension . The median age of the included patients was 60.5 years, and the cohort included 49 women (59.8 %) and 33 (40.2 %) men . Hypertension (31 [28.2 %] ) was the most common chronic illness, followed by diabetes (16 [19.5 %] ) and cardiovascular disease (15 [18.3 %] ). The most common symptoms were fatigue (55 [67.1 %] ), dry cough (46 [56.1 %] ) and fever ≥ 37.3 °C (46 [56.1 %] ). The median time from illness onset to positive RT-PCR test was 13.0 days (range 3-25 days). There were 6 deaths (20.7 %) in the hypertension group and 5 deaths (9.4 %) in the nonhypertension group, and more hypertensive patients with COVID-19 (8 [27.6 %] ) than nonhypertensive patients (2 [3.8 %] ) (P = 0.002) had at least one comorbid disease . Compared with nonhypertensive patients, hypertensive patients exhibited higher neutrophil counts, serum amyloid A, C-reactive protein, and NT-proBNP and lower lymphocyte counts and eGFR . Dynamic observations indicated more severe disease and poorer outcomes after hospital admission in the hypertension group . COVID-19 patients with hypertension have increased risks of severe inflammatory reactions, serious internal organ injury, and disease progression and deterioration.