Background Ferritin even though widely recognized as a representative of total body iron stores, its prognostic utility is linked with COVID-19 . This study was aimed at evaluation of the association of ferritin with severity in Coronavirus disease 2019 (COVID-19), hospitalized patients and to test the hypothesis that it is an independent predictor of mortality . Material and methods This study was conducted at Chemical Pathology, Department of Pathology and Laboratory Medicine, Aga Khan University (AKU), Karachi . Medical records of all in-patients including both genders, and all age groups with documented COVID-19 from 1st March to 10th August 2020 were reviewed . The subjects were divided into two categories severe and non-severe COVID-19; and survivors and non-survivors . The details were recorded on a pre-structured performa . Between-group differences were tested using the Mann–Whitney's U-test . The receiver operating characteristic curve was plotted for ferritin with severity and mortality . A binary logistic regression was used to identify variables independently associated with mortality . The data was analyzed using Statistical Package for the Social Sciences (SPSS). Results A total of 336 in patients were reviewed as declared COVID-19 positive during the study duration, and 157 were included in the final analysis including 108 males and 49 females . Statistically significant difference in ferritin was found in the two categories based on severity and mortality . Binary logistic regression showed ferritin to be an independent predictor of all-cause mortality supplemented with an AUC of 0.69 on ROC analysis . Conclusions Serum ferritin concentration is a promising predictor of mortality in COVID-19 cases.