Background This systematic review and meta-analysis aimed to assess the association between the tricuspid annular plane systolic excursion (TAPSE) measured by echocardiography and mortality in COVID-19 . Methods We performed a systematic literature search using PubMed, Embase, and Scopus databases with keywords``COVID-19"OR``SARS-CoV-2"OR “ 2019-nCoV ” AND “ Tricuspid annular plane systolic excursion ” OR “ TAPSE ” up until 20 January 2021 . The main outcome was mortality; the effect estimate was reported in hazard ratio (HR) which was pooled from the unadjusted and adjusted effect estimate retrieved from the included studies . Mean difference of the TAPSE (in mm) between non-survivors and survivors were pooled . Results There were 641 patients from 7 studies included in this systematic review and meta-analysis . TAPSE was lower in non-survivors compared to survivors (mean difference -3.74 [-5.22, -2.26], p <0.001; I2 : 85.5%, p <0.001). Each 1 mm decrease in TAPSE was associated with increased mortality (HR 1.24 [1.18 , 1.31], p <0.001; I2 : 0.0%, p = 0.491). In pooled adjusted model, each 1 mm decrease in TAPSE was associated with increased mortality (HR 1.21 [1.11 , 1.33], p <0.001; I2 : 45.1%, p = 0.156). Meta-regression indicates that the difference in TAPSE between the non-survivors and survivors were affected by COPD (-0.183, p <0.001) and PASP (-0.344, p = 0.039). but not age (p = 0.668), male (p = 0.821), hypertension (p = 0.101), diabetes (p = 0.603), CAD (p = 0.564), smoking (p = 0.140), and LVEF (p = 0.452). Conclusion Every 1 mm decrease in TAPSE was associated with approximately 20% increase in mortality . PROSPERO ID CRD42021232194.