While primarily a respiratory illness, infection with the novel coronavirus (COVID-19) is associated with pathologic changes in normal coagulation, characterized by both thromboembolic and bleeding events . We present the case of a 22-year-old female diagnosed with renal angiomyolipoma (AML) rupture 2 weeks after COVID-19 infection, ultimately requiring admission for hemorrhage control via endovascular embolization . Emergency medicine physicians should maintain a high index of suspicion for renal AML rupture and other spontaneous bleeding events in patients with recent COVID-19 infection due to a possible correlation between the two.