Nosocomial infections, also known as hospital-acquired infections, pose a serious challenge to healthcare professionals globally during the Coronavirus disease 2019 (COVID19) pandemic . Nosocomial infection of COVID19 directly impacts the quality of life of patients, as well as results in extra expenditure to hospitals . It has been shown that COVID19 is more likely to transmit via close, unprotected contact with infected patients . Additionally, current preventative and containment measures tend to overlook asymptomatic individuals and superspreading events . Since the mode of transmission and real origin of COVID19 in hospitals has not been fully elucidated yet, minimizing nosocomial infection in hospitals remains a difficult but urgent task for healthcare professionals . Healthcare professionals globally should form an alliance against nosocomial COVID19 infections . The fight against COVID19 may provide valuable lessons for the future prevention and control of nosocomial infections . The present review will discuss some of the key strategies to prevent and control hospitalbased nosocomial COVID19 infections.