This retrospective cohort study included all the subjects diagnosed with severe acute respiratory syndrome coronavirus 2 infection (n=2493) in 2 Italian provinces Two hundred fifty-eight persons died, after a median of 14 0±11 0 days Adjusting for age, gender, and main comorbidities, the ≥28-day case-fatality rate did not decrease from March to April 2020 (adjusted hazard ratio , 0 93; P= 6) © 2020 The Author (s) Published by Oxford University Press on behalf of Infectious Diseases Society of America