Background: A coronavirus pandemic has reached all over the world It is a highly contagious virus spreading from human to human by respiratory droplet infection and close contact Applying preventive measures is very important in tackling the spread of the disease since there is no curative antiviral drug The pandemic of the virus has impacted different institutions including the university To overcome the impact, students are resuming face to face education by applying preventive measures of Covid-19 This study is undertaken to assess KAP in Mizan Tepi University, 2020 Materials and

Methods: A cross-sectional study was conducted among 402 randomly selected participants A structured questionnaire was used to collect the data from December 1-10/2020 Data were entered into Epidata 3 1 and exported to SPSS version 21 for analysis Bivariate and multivariate logistic regressions were used for analyses A p-value of less than 0 05 was used to identify significant variables in multivariate logistic regression analysis

Results: In this study , 47% , 54%, and 42 8% of the students had good knowledge, positive attitude, and good practice towards Covid-19, respectively Being from health sciences (AOR= 2 983 , 95% CI (1 869 , 4 763) ) was significantly associated with good knowledge Being from health sciences (AOR= 1 86 , 95% CI (1 169 , 2 970) ), female sex (AOR=0 628 , 95% CI (0 405 , 0 975) ), at least one parent having diploma or degree (AOR= 0 455 , 95% CI (0 236 , 0 878) ), and 1000-1500 ETB monthly income (AOR= 0 403 , 95% CI (0 189 , 0 856) ) were significantly associated with students' attitude Being rural residence (AOR = 1 740 , 95% CI (1 136 , 2 663) ), positive knowledge (AOR=1 893 , 95% CI (1 2322 909) ), and positive attitude (( AOR=2 676 , 95% CI (1 745 , 4 105) ) were positively associated with the students practice Conclusion: The KAP of the students towards the Covid-19 was low Being a health sciences student was an explanatory variable for better knowledge Sex, being a health science college student, parents' educational status, and monthly income were predictors of students' attitude Residency, knowledge, and attitude were independent predictors of practice Awareness creation on preventive behaviors among the students is highly recommended