A young man presented to our centre needing an urgent debridement of his postcraniotomy wound due to massive myiasis during the COVID-19 pandemic in October 2020 . Prior to the surgery, his nasopharyngeal swab real-time PCR test result was unknown . One day later, it returned as SARS-CoV-2 positive . All healthcare workers who were involved in the patient management avoided cross infection as they wore appropriate personal protective equipment . This article depicts the importance of adequate preparations when handling potentially infectious patients and the perioperative issues associated with it.